As we age, especially after age 35 years, many hormone levels in the body decline. Hormones are chemical messengers that run the body. When hormone levels decline, this leads to less efficiency. Less efficiency leads to declining function. Declining function can eventually lead to change in form and function, which can result in degeneration, disease, aging, and breakdown. Testosterone is a vital anabolic hormone that helps to promote growth of muscle, skin, and other tissues in the body. It also promotes proper glucose metabolism, sex drive, joy and positive mood. Often men supplement DHEA and androstenedione to boost declining hormone levels of DHEA and testosterone. This can sometimes be a mistake.

Dr. Bob was a MD internal medicine, orthomolecular doctor, MD psychiatrist, chiropractor, and healer 65 years. He was a diabetic who lived to 108 years with only 1 side effect 2 years before he passed away. Dr. Bob practiced a system of medicine called orthomolecular medicine. It is a system of medicine that uses mainly natural substances that are non-toxic and safe in wide range of doses. It uses mainly herbs and minerals/vitamins.

There is an article on this web site called, "Estrogen-Testosterone Syndrome/Potbelly/Baldness Cure." The following is an excerpt to indicate when DHEA and androstenedione perhaps should not be supplemented or used, for DHEA or testosterone replacement therapy. Dr. Bob advised there are times where testosterone replacement therapy should not be advised, even when testosterone levels fall below minimum standards. Dr. Bob called this exception the, "potbelly/ baldness syndrome-estrogen/testosterone syndrome."

"There are times in men when abnormally high levels of estrogen are being produced and negative changes in his biologically active estrogen and testosterone ratios occur. Some of these times can be when chronic liver disease, hyperthyroidism, decrease in androgens, excess body fat, advancing age, and/or hypothyroidism are present. These conditions can also effect sex hormone-binding globulin (SHBG), by increasing its production. SHBG binds testosterone and estradiol (one of women's estrogens). The amount of testosterone and estradiol free in the bloodstream, are the biologically active forms of the hormones. Therefore, the more bound testosterone, the more restriction of the free concentration of testosterone in serum. Testosterone binds to SHBG with higher affinity than does estradiol. Therefore, a change in the level of SHBG creates a greater change in free testosterone levels than in estradiol levels. An increase of SHBG may contribute to the increased free estrogen-testosterone ratio, and hence contribute to the symptoms of estrogenization, such as enlarged breasts (known to bodybuilders as bitch tits). (Ref. Robert K. Murray, MD, Ph.D., Daryl K. Granmer, MD, Peter A. Mayes, Ph.D., D.Sc., Victor W. Fodwell, Ph.D., Harper's Biochemistry, twenty-fifth edition. Appleton & Lance, Stanford, Connecticut, 2000.)"

Dr. Bob noted when men had enlarged breasts, were advancing in age, had low testosterone levels, potbellies, and were balding (Note - Normal or high testosterone levels can also lead to estrogenization. So baldness, enlarged breasts, pear shape (potbelly), and so on, and other feminization characteristic are the clues to watch out for higher levels of bound testosterone - lower levels of free testosterone - higher levels of free estrogen.) - particularly in the rear of the head, that this could be a sign of future cancer, particularly prostrate cancer. What Dr. Bob believed was happening when he saw these symptoms, was higher levels of estrogen-testosterone ratios were appearing. He believed that because testosterone had greater affinity to being bound by proteins in the bloodstream, that adding testosterone as a replacement therapy in these particular cases could lead to more estrogen aromatization taking place (androgens producing estrogen-in human males, the peripheral aromatization of testosterone to estradiol accounts for 80% of the production of latter-Harper's Biochemistry, page 601), because testosterone had a greater affinity to being bound by proteins (SHBG) in the bloodstream, increasing the ratio of estrogen-to-testosterone in the active biological forms.

To Put All This More Simply.

In the cases of increasing higher levels of estrogen-to-testosterone in men, testosterone therapy can result in increasing testosterone levels, resulting in more aromatization of the testosterone to estrogen! This means the more testosterone added, the more estrogen produced in ratio to testosterone. In this case, testosterone replacement therapy would be increasing estrogen levels in the bloodstream in relation to testosterone levels. Since estrogen can result in certain cancers in men, such as prostrate cancers, then testosterone replacement therapy can be dangerous for certain men who may aromatize the testosterone replacement and also testosterone replacement will not work as natural.  DHEA and androstenedione can produce testosterone. In some cases this might result in the aromatization of testosterone to estrogen!

In conclusion, when supplementing DHEA and androstenedione, consult a hormonal specialist or endocrinologist. Although famous personalities such as the baseball player Mark McQuire have broadcast their use of supplementation such as androstenedione, in certain cases DHEA and androstenedione can lead to cancers.

Doctor's Note - Arimidex can be effective in helping restore free testosterone levels and helping restore potency in type II diabetics. This may work where penile injections, testosterone shots, Viagra, hypnotism, and everything short of vascular operations and implants have failed. Sometimes Arimidex may be the only thing that works. Please note --blood sugar in some type II diabetics goes down to near normal levels because testosterone is a hormone, which modulates excess glucose levels as well as builds muscles mass - you will burn more glucose more effectively. This is great news for impotent type II diabetics! Especially with potbellies.


Note – In order for these anti-aging ideas to be successful, you must use supplements of the highest quality. Dr. Bob often said, "almost all supplement companies produce poor quality." You can consider the product page of this web site. Almost all the products met Dr. Bob’s approval. Since he passed away we have attempted to keep the same high standards.

WARNING:  DO NOT STOP ANY TREATMENT OR MEDICATION YOU CURRENTLY USE.  CONSULT WITH YOUR DOCTOR BEFORE STARTING THE USE OF SUPPLEMENTS. 

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