Oxidation of L-dopa in Parkinson's Disease

Parkinson's Disease is a disease of accelerated aging.  Degeneration of the brain, decline of cognitive function, motor symptoms, and other problems lead to decreased efficiency and function of the brain and body.  This leads to a downward spiral of further decrease in efficiency and function, which results in degeneration, aging, breakdown, and death. 

There is no magic bullet cure for Parkinson's.  Each symptom or problem from

Parkinson's needs to be addressed and neutralized, which will help decrease stress from Parkinson's and help slow down aging and degeneration.  In Parkinson's, the primary problem is low levels of the neurotransmitter (chemical brain messengers) dopamine, which ultimately results in most of the symptoms of Parkinson’s.  The body produces dopamine from the amino acid L-dopa.  L-dopa is one of a series of precursors or building blocks used by the body to manufacture the neurotransmitters dopamine and norepinephrine, and the hormone epinephrine.  It can be considered one link in a chain of several chemicals, each of which is converted by metabolic processes into the next. 

The chain begins with the essential amino acid phenylalanine, found in the human diet.  The body produces tyrosine (an amino acid), from phenylalanine.  Tyrosine is metabolized into L-dopa.  One of the major problems in Parkinson's is very little L-dopa is converted into dopamine, because L-dopa is oxidized, a process in the body that converts L-dopa into other metabolites rather than dopamine.     Brain dopamine levels cannot be increased by administering dopamine directly because it does not cross the

blood/brain barrier.  Therefore, dopamine levels rely on the conversion of L-dopa to dopamine, and if a great deal of L-dopa is oxidized before it can convert to dopamine, then this will lead to lower dopamine levels. 

Dr. Bob was a MD internal medicine, orthomolecular doctor, MD psychiatrist, chiropractor, and healer 65 years.  He was a diabetic who lived to 108 years with only 1 side effect 2 years before he passed away.  Dr. Bob practiced a system of medicine called orthomolecular medicine.  It is a system of medicine that uses mainly natural substances that are non-toxic and safe in wide range of doses.  It uses mainly herbs and minerals/vitamins. 

Dr. Bob advised, when supplementing L-phenylalanine and tyrosine, to supplement at the same time gamma-aminobutyric acid (GABA).  From Oxford Dictionary of Biology, "GABA is an inhibitory neurotransmitter in the central nervous system (principally the brain)."   Dr. Bob explained that GABA can help inhibit the processes that lead to the oxidation of L-phenylalanine, tyrosine, and L-dopa, before they can produce dopamine..  

Also the low levels of dopamine, in Parkinson's, is believed to lead to overstimulation of the neurotransmitter acetylcholine.  The overstimulation of acetylcholine is believed to lead to the motor symptoms of Parkinson's.  GABA can help decrease the overstimulation of neurotransmitters such as acetylcholine and Dr. Bob advised it in Parkinson's to help inhibit acetylcholine.   

In conclusion, Dr. Bob advised to consider GABA as a supplement to help prevent the oxidation of L-dopa and also as a method to inhibit acetylcholine.  Good luck. 

Note – you can consider precursors to raise GABA levels.  Consult with a doctor to carefully monitor your GABA levels.

Note – In order for these anti-aging ideas to be successful, you must use supplements of the highest quality. Dr. Bob often said, "almost all supplement companies produce poor quality." You can consider the product page of this web site. Almost all the products met Dr. Bob’s approval. Since he passed away we have attempted to keep the same high standards.

WARNING:  DO NOT STOP ANY TREATMENT OR MEDICATION YOU CURRENTLY USE.  CONSULT WITH YOUR DOCTOR BEFORE STARTING THE USE OF SUPPLEMENTS. 

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The Food and Drug Administration has not evaluated any of the statements contained on this web site. The information contained in this article is not intended to diagnose, treat, cure or prevent any disease. Remember each person's body is different and will react differently to various herbal, vitamin and mineral supplements. Therefore, any supplementation must be administered on an individual basis. Use the information found on this web site as precisely that: Information. You and your doctor must make any final decisions. This information is not meant to replace any doctor and patient consultation. This information should in no way replace your personal physician's advice.

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Page Last Modified: 22JAN02