GW-501516 (Cardarine)

GW-501516-(Cardarine)This article would shed more light on the drug Cardarine with numerical call number GW-501516, detailing all you need to know.

What is GW-501516 (Cardarine)

GW-501516 or Cardarine(1) as it’s called was developed in the 1990s by a joint effort of two pharmaceuticals powerhouses GlaxoSmithKline and Ligand Pharmaceuticals. Originally set in motion at clinical developmental stages as a drug to forestall cardiovascular diseases especially tumor formation in different parts of the body like breasts, colon, and prostate.

By the early 2000s, further studies conducted on GW 501516 indicated that like other PPAR agonists, it is able to stop metabolic diseases like diabetes and obesity. A test conducted by a Ronald M. Evans’s laboratory on mice led to the discovery that the compound resulted in an increased physical performance. While researchers continue to test Cardarine, bodybuilders have adopted it, hailing it as the “ultimate endurance enhancing supplement.”

With Cardarine’s many benefits like enhancing recovery, increase endurance, and burn off excess fats which seem well suited for athletes, it has become a sort of indispensable toolkit for every athlete. While GW-5015156 is not a regular at your drugstore, there haven’t been any confirmed harmful side effects found in over 20 years of its existence making it one of sport’s most sort-after drugs.

How it works

It’s important to note that GW 501516 isn’t a SARM but a selective PPARδ agonist(2) that does work in similar ways. The GW-501516 focuses on those receptors which stimulate skeletal muscle tissue and glucose uptake. Due to its ability to rapidly melt through fatty acid oxidation, it’s currently suggested to become a potential treatment for obesity.

It’s also noteworthy that Cardarine GW501516 is claimed to increase the high-density lipoproteins (HDL) which is regarded as the good cholesterol by an average of 79% and decreases the low-density lipoproteins (LDL) regarded as the bad cholesterol in Phase II trials.

studies on cardarine

Effects of GW501516 on mRNA expression in HSKM cells

Benefits of GW-501516

For enthusiasts of this power-drug, the GW-501516 indeed has a long line-up of benefits applicable in medical science for the treatment of cardiovascular diseases and in sports to boost performance. There have been several studies performed on this wonder drug with most showing different positive effects during these phases of trials while exhibiting the minimum side effects.

We have compiled a list of GW-501516 benefits that stand out which users of this ‘supplement’ will most likely experience.

Endurance Supplement Like Never Before

When it comes down to endurance, stamina, energy, and performance enhancement, the GW-501516 literally rules the game. Used by professional athletes including bodybuilders and cyclists the GW-501516 is renowned for working effectively. It’s notorious for being hyper-effective that the world anti-doping agency (WADA) has added it to its index of banned substances.

With the GW-501516 you get shorter recovery times after an intensive workout session in the gym. Also, because it’s not a stimulant, you can expect to last hours without crashing. The energy gotten from this supplement doesn’t make you anxious or jittery.

Different users have experienced different positive results and an interesting result is one where users say they experienced a feeling of calmness and a sense of well being.

Other benefits include:

  • The first dose gets a noticeable result
  • It’s long lasting, able to run for a stretch of up to 12 weeks
  • It melts fat rapidly and is non-catabolic
  • You can use it while bulking or cutting
  • Can be stacked due to its versatility
  • Doesn’t require a post cycle therapy (PCT)
  • There are no noticeable side effects as suggested

Side Effects & Cancer

There have been rumors that the GW-501516 has several side effects including the widespread concern that it is linked to cancer and tumor development. The root cause of this rumor being its ability to improve the Angiogenesis in the body at rates considered being extremely high and rates at which cancerous cells develop in the colons of mice.

Scientists were of the notion that if a patient had tumor cells active in their body, they are likely to be susceptible to angiogenesis thereby causing the cancerous tumor to grow at an increased rate. This had resulted in several more experiments conducted to prove the possibility of this hypothesis. However, till date, all have been unsuccessful.

Recently published studies have discredited and rubbished the initial 1996 report that stemmed this rumor. For instance, the American Association of Cancer Research published a study in 2004 which stated that:

“…PPAR agonists have shown no effect on the proliferation of colorectal cancer cells…” it also added, “…under normal culture conditions, PPAR activation has no effect on cell growth.”

An experiment carried out on human colon cancer and breast cancer cells, showed that the PPAR agonist GW-501516 was not only safe to use but was also proven to hamper the growth of cancer cells. That said, the National Institute of Health (NIH) has confirmed that GW-501516 discourage the growth of a multitude of cancerous cells in humans.

After over two decades of testing, there’s yet to be any recorded side effects.

Dosing Guidelines and Recommendations

  • Lab mice dosages should be administered 45 minutes to 1 hour prior to exercise.
  • A 10 to 20 mg dose per day is sufficient. It’s advisable, to begin with, 10 mg per day which is aimed at endurance. For fat loss, a higher dosage around the 20 mg mark should suffice.
  • GW-501516 was created to be used long term and can be used as such without off-cycling. Its effects do not dwindle over time according to a 2-year study.
  • To use GW-501516, it’s strongly recommended you are on a ketogenic diet.
  • It has a half-life of between 16 to 24 hours. It’s recommended to take a 10 mg pill once a day or a 10 mg pill once in 10 to 12 hours if you require a higher dose.
  • It doesn’t require PCT. However if you have ingested highly toxic anabolics, it is recommended to combine Cardarine with PCT.
  • You can use it together with any type of stimulants and anabolics without adverse effects.


A major competitive edge of Cardarine is its ability to be used with just about anything. It can be used together with cutting, recomping and bulking.

Using it for bulking cleans up your gains giving you a cleaner bulk whilst keeping size constant.  Adding it to your cutting stack keeps your muscle mass constant and prunes down excess fat. Stacking with recomping is ideal if you’d love to build lean muscle.

Rounding up

With a rave of reviews from users and the interesting fact that there hasn’t been any proof of a side effect after the use of GW-501516, it’s safe to say that this supplement is the real king of endurance and fat burners. GW allows you get the desired results you crave by improving your endurance so you can lift harder and longer while recuperating super quickly.


  1. Cardarine (GW501516), George Spellwin,
  2. Selective PPARδ agonist,


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